Centers around Blossom Russo's life at school and at home. She lives with her single father, charming musician Nick Russo, who tries hard to be the perfect parent, and her two elder brothers. Anthony is the cool, older brother. Joey is sweet and naive. Six LeMeure is Blossom's best friend. Six is emotionally neglected at her home and spends most of her time around at the Russo's. Six is the voice of mischief and is often Blossom's partner in crime.